Journal
CHEMICAL COMMUNICATIONS
Volume 55, Issue 70, Pages 10472-10475Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc04871e
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Funding
- National Natural Science Foundation of China [21701195, 21572282, 21601210]
- 973 program [2015CB856301]
- Innovative Research Team in University of Ministry of Education of China [IRT_17R111]
- Guangdong Natural Science Foundation [2017A030310278]
- Special Funds for the Cultivation of Guangdong College Students' Scientific and Technological Innovation [pdjha0005]
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A mitochondria-targeted photodynamic therapy (PDT) agent was designed and synthesized. Upon light irradiation, it can produce photoacid and its photolysis products can further sensitize O-1(2) generation, causing dual-mode (oxygen-independent and oxygen-dependent) photodynamic damage in mitochondria and killing cancer cells effectively even under hypoxic conditions.
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