Journal
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Volume 119, Issue -, Pages 107-112Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jri.2016.06.008
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Funding
- Deutsche Forschungsgemeinschaft [BH 93/1-1, GRK 1871]
- Medical Faculty of Justus-Liebig-University of Giessen
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Testicular macrophages are the largest leukocyte population in the testis. Their environment is characterized by the seemingly contradictory needs for tolerance against the autoantigenic germ cells and the capacity to mount pro-inflammatory innate immune responses against invading pathogens. During the pa-St years considerable progress has been made in our understanding how intracellular signaling events enable testicular macrophages to adequately respond to inflammatory stimuli with the capacity to clear pathogens, but avoid excessive tissue damage to maintain fertility. Moreover, new data add to our understanding that testicular macrophages play essential roles in normal testis homeostasis and fetal testicular development. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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