Journal
IN VIVO
Volume 33, Issue 5, Pages 1691-1696Publisher
INT INST ANTICANCER RESEARCH
DOI: 10.21873/invivo.11657
Keywords
B-Type natriuretic peptide; hyperparathyroidism; parathyroidectomy; age
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Funding
- Ministry of Science and Technology of Taiwan [MOST-106-2314-B-715-008-MY3]
- Mackay Medical College [1071B24]
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Background/Aim: Parathyroidectomy has beneficial effects on all-cause and cardiovascular mortality in patients with uncontrolled hyperparathyroidism. B-Type natriuretic peptide (BNP) correlates with the severity of heart failure. We aimed to investigate whether parathyroidectomy modulates the BNP levels in dialysis patients. Patients and Methods: Patients who underwent surgical intervention for hyperparathyroidism were included. The serum BNP levels were determined before parathyroidectomy and during follow-up. Results: The preoperative and postoperative BNP levels were 499 +/- 561 and 453 +/- 442 pg/ml, respectively (p=0.82). The baseline BNP level was positively correlated with weakness and headache, but not biochemical parameters. In multivariate analysis, age (odds ratio=0.837) and preoperative symptom score (odds ratio=0.935) were independent predictors for the postoperative decline in BNP levels Conclusion: The serum BNP levels may increase or decrease after parathyroidectomy. Younger age and lower symptom burden are associated with decline in BNP levels.
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