Journal
REACTION CHEMISTRY & ENGINEERING
Volume 4, Issue 9, Pages 1571-1578Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9re00087a
Keywords
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Funding
- Land Steiermark/Zukunftsfonds Steiermark [9003]
- Austrian Federal Ministry of Transport, Innovation and Technology (BMVIT) [862766]
- Austrian Federal Ministry of Science, Research and Economy (BMWFW) [862766]
- State of Styria (Styrian Funding Agency SFG) [862766]
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Currently, the monitoring of multistep continuous flow processes by multiple analytical sources is still seen as a resource intensive and specialized activity. In this article, the coupling of a modular microreactor platform with real-time monitoring by inline IR and NMR, in addition to online UPLC, is described. Using this platform, we rapidly generated experimental data (17 iterations in under 2 hours) to access information on the different chemical species at multiple points within the reactor and to generate process understanding. We highlight the application of the platform in the optimization of a multistep organolithium transformation. The optimized continuous flow conditions were demonstrated in a scale-out experiment with in-process monitoring to afford the desired product in 70% isolated yield and provided a throughput of 4.2 g h(-1).
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