Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 17, Issue 35, Pages 8094-8105Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9ob01133a
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Funding
- Wellcome Trust ISSF
- Trinity College Dublin
- Ussher Postgraduate fellowship
- Science Foundation Ireland [IvP 13/IA/1894, 15/CDA/3310]
- CRUK [C9047/A24759]
- BBSRC [BB/J001694/2] Funding Source: UKRI
- Science Foundation Ireland (SFI) [15/CDA/3310] Funding Source: Science Foundation Ireland (SFI)
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Nine modified nucleosides, incorporating zinc-binding pharmacophores, have been synthesised and evaluated as inhibitors of the DNA repair nuclease SNM1A. The series included oxyamides, hydroxamic acids, hydroxamates, a hydrazide, a squarate ester and a squaramide. A hydroxamic acid-derived nucleoside inhibited the enzyme, offering a novel approach for potential therapeutic development through the use of rationally designed nucleoside derived inhibitors.
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