Journal
JOURNAL OF PSYCHOPHARMACOLOGY
Volume 31, Issue 9, Pages 1121-1136Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0269881117699612
Keywords
Serotonin 5-HT; midbrain raphe nucleus; neural circuit; multiscale computational model
Funding
- BBSRC [BB/P003427/1]
- COST Action Open Multiscale Systems Medicine (OpenMultiMed) - COST (European Cooperation in Science and Technology)
- Northern Ireland Functional Brain Mapping Facility - Invest NI [1303/101154803]
- University of Ulster
- NSFC [31671077, 31511130066]
- Royal Society - NSFC International Exchanges
- Human Frontier Science program, Precursory Research for Embryonic Science and Technology, Strategic Research Program for Brain Sciences by the Ministry of Education, Culture, Sports, Science and Technology of Japan
- BBSRC [BB/P003427/1] Funding Source: UKRI
Ask authors/readers for more resources
Despite its importance in regulating emotion and mental wellbeing, the complex structure and function of the serotonergic system present formidable challenges toward understanding its mechanisms. In this paper, we review studies investigating the interactions between serotonergic and related brain systems and their behavior at multiple scales, with a focus on biologically-based computational modeling. We first discuss serotonergic intracellular signaling and neuronal excitability, followed by neuronal circuit and systems levels. At each level of organization, we will discuss the experimental work accompanied by related computational modeling work. We then suggest that a multiscale modeling approach that integrates the various levels of neurobiological organization could potentially transform the way we understand the complex functions associated with serotonin.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available