4.7 Article

Ratiometric two-photon fluorescent probe for in situ imaging of carboxylesterase (CE)-mediated mitochondrial acidification during medication

Journal

CHEMICAL COMMUNICATIONS
Volume 55, Issue 76, Pages 11358-11361

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc05759e

Keywords

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Funding

  1. National Natural Science Foundation of China [21475074, 21403123]
  2. China Postdoctoral Science Foundation [2017M622254, 2016M600531]
  3. Open Funds of the Shandong Province Key Laboratory of Detection Technology for Tumor Markers [KLDTTM2015-6, KLDTTM2015-9]
  4. Natural Science Foundation of Shandong Province [ZR201709240033]
  5. Royal Society

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We report on a dual ratiometric two-photon fluorescent probe for in situ sensing of mitochondrial CE activity and pH. Using the probe it is possible to visualize the CE-mediated acidification of hepatoma cells and hepatic tissues during medication with antipyretic anti-inflammatory drugs.

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