Journal
JOURNAL OF PSYCHIATRIC RESEARCH
Volume 86, Issue -, Pages 58-65Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jpsychires.2016.11.010
Keywords
Depression; Childhood adversity; MRI; Caudate; Hippocampus; ENIGMA
Categories
Funding
- NIH BD2K award [U54EB020403]
- Geestkracht program of the Netherlands Organisation for Health Research and Development [10-000-1002]
- VU University Medical Center
- GGZ inGeest
- Arkin
- Leiden University Medical Center
- GGZ Rivierduinen
- University Medical Center Groningen
- mental health care organizations
- Netherlands Brain Foundation [F2014(1)-24]
- VENI grant (NWO) [016.156.077]
- Australian National Health and Medical Research Council [496682, 1009064, 464914]
- US National Institute of Child Health and Human Development [R01HD050735]
- US National Institute on Drug Abuse [R00DA023549]
- University of Queensland International PhD scholarship
- Lundbeck and the German Research Foundation [WA 1539/4-1, SCHN 1204/3-1]
- Deutsche Forschungsgemeinschaft/German Research Association [SCHR443/11-1]
- Exzellenz-Stiftung of the Max Planck Society
- Federal Ministry of Education and Research (BMBF) of the National Genome Research Network (NGFN) [FKZ 01GS0481]
- German Federal Ministry of Education and Research [01ZZ9603, 01ZZ0103, 01ZZ0403]
- Ministry of Cultural Affairs
- Social Ministry of the Federal State of Mecklenburg West Pomerania
- Siemens Healthcare, Erlangen, Germany
- German Research Foundation [GR1912/5-1]
- Netherlands Organisation for Scientific Research (NWO - ZonMW, VIDI) [017.106.370]
- Erasmus MC fellowship
- ZonMW clinical fellowship [90700435]
- Medical Research Council of South Africa
- European Union Marie Curie International Training
- Science Foundation Ireland (SFI) through a SFI-Stokes Professorship
- Health Research Board Ireland (HRB)
- German Research Foundation (DFG) [FOR 2107, DA1151/5-1]
- Innovative Medizinische Forschung (IMF) of the Medical Faculty of Mbnster [DA120903, DA111107, DA211012]
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Childhood adversity plays an important role for development of major depressive disorder (MDD). There are differences in subcortical brain structures between patients with MDD and healthy controls, but the specific impact of childhood adversity on such structures in MDD remains unclear. Thus, aim of the present study was to investigate whether childhood adversity is associated with subcortical volumes and how it interacts with a diagnosis of MDD and sex. Within the ENIGMA-MDD network, nine university partner sites, which assessed childhood adversity and magnetic resonance imaging in patients with MDD and controls, took part in the current joint mega-analysis. In this largest effort world-wide to identify subcortical brain structure differences related to childhood adversity, 3036 participants were analyzed for subcortical brain volumes using FreeSurfer. A significant interaction was evident between childhood adversity, MDD diagnosis, sex, and region. Increased exposure to childhood adversity was associated with smaller caudate volumes in females independent of MDD. All subcategories of childhood adversity were negatively associated with caudate volumes in females - in particular emotional neglect and physical neglect (independently from age, ICV, imaging site and MDD diagnosis). There was no interaction effect between childhood adversity and MDD diagnosis on subcortical brain volumes. Childhood adversity is one of the contributors to brain structural abnormalities. It is associated with subcortical brain abnormalities that are relevant to psychiatric disorders such as depression. (C) 2016 Published by Elsevier Ltd.
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