Journal
ANALYST
Volume 144, Issue 18, Pages 5373-5377Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9an01174a
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Funding
- NSFC [21472067, 21672083, 21877048]
- Natural Science Foundation of Shandong Province [ZR2018BB022, ZR2018BB058]
- Taishan Scholar Foundation [TS201511041]
- University of Jinan [309-10004, 1009428]
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Lipid droplets are known to play an important role in many cellular activities, as revealed by recent studies. Additionally, hexavalent chromium is considered extremely toxic because it readily passes through cellular membranes and easily accumulates in living cells. In this study, a novel lipid droplet-targeted fluorescent probe (Si-LDS) for recognition of Cr6+ in living cells was designed and synthesized using triphenylamine derivatives and organosiloxane. Si-LDS detected Cr6+ with high selectivity and sensitivity. The novel probe was successfully applied to cell imaging of exogenous Cr6+ in HeLa cells, and Si-LDS was able to localize mainly in the lipid droplets of HeLa cells. Si-LDS is the first lipid droplet-targeted fluorescent probe for monitoring Cr6+.
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