Journal
JOURNAL OF PROTEOME RESEARCH
Volume 17, Issue 1, Pages 568-578Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jproteome.7b00685
Keywords
proteoform; identification; quantification; visualization; modification; PTM; NeuCode; intact mass; lysine count
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Funding
- National Institute of General Medical Sciences [RO1GM114292]
- Computation and Informatics in Biology and Medicine Training Program [T15LM007359]
- Biotechnology Training Program [T32GM008349]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM008349, R01GM114292] Funding Source: NIH RePORTER
- NATIONAL LIBRARY OF MEDICINE [T15LM007359] Funding Source: NIH RePORTER
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We present an open-source, interactive program named Proteoform Suite that uses proteoform mass and intensity measurements from complex biological samples to identify and quantify proteoforms. It constructs families of proteoforms derived from the same gene, assesses proteoform function using gene ontology (GO) analysis, and enables visualization of quantified proteoform families and their changes. It is applied here to reveal systemic proteoform variations in the yeast response to salt stress.
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