Journal
C-JOURNAL OF CARBON RESEARCH
Volume 5, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/c5010001
Keywords
green routes; magnetic nanoparticles; drug delivery; cancer therapy; doxorubicin
Categories
Funding
- FEDER through COMPETE2020 - POCI [POCI-01-0145-FEDER-006984]
- FCT (Fundacao para a Ciencia e a Tecnologia)
- Programa Operacional Regional do Norte-Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF)
- FCT
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In this study, hydrophilic magnetic nanoparticles were synthesized by green routes using a methanolic extract of Rubus ulmifolius Schott flowers. The prepared magnetic nanoparticles were coated with carbon-based shell for drug delivery application. The nanocomposites were further chemically functionalized with nitric acid and, sequentially, with Pluronic((R)) F68 (CMNPs-plur) to enhance their colloidal stability. The resulting material was dispersed in phosphate buffer solution at pH 7.4 to study the Doxorubicin loading. After shaking for 48 h, 99.13% of the drug was loaded by the nanocomposites. Subsequently, the drug release was studied in different working phosphate buffer solutions (i.e., PB pH 4.5, pH 6.0 and pH 7.4) to determine the efficiency of the synthesized material for drug delivery as pH-dependent drug nanocarrier. The results have shown a drug release quantity 18% higher in mimicking tumor environment than in the physiological one. Therefore, this study demonstrates the ability of CMNPs-plur to release a drug with pH dependence, which could be used in the future for the treatment of cancer in situ by means of controlled drug release.
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