Journal
2019 IEEE 16TH INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING (ISBI 2019)
Volume -, Issue -, Pages 126-130Publisher
IEEE
DOI: 10.1109/isbi.2019.8759513
Keywords
multi-shell; diffusion MRI; infant; tract clustering; maternal depression
Funding
- NIH [R21MH111978, R21HD090493, ROINS100952, P41 EB015922]
Ask authors/readers for more resources
Maternal depression is a well-documented risk factor for psychopathology in children. The origins of this association, however, arc not well understood. Non-invasive imaging methods such as MRI can be used to assess infant brain development and examine associations between maternal depression and neurobiological correlates of risk for psychopathology in early life. Here, we present preliminary analyses on 24 6 month old infants using a multi-shell diffusion MRI sequence optimized for imaging infant white matter, along with a novel tract clustering and identification workflow, TractStat. We examine the association between maternal depressive symptoms, measured by the Edinburgh Postnatal Depression Scale, and infant white matter organization in the uncinate fasciculus (UF). Infants whose mothers report experiencing more severe depressive symptoms have lower fractional anisotropy of the right UF, suggesting a possible neurobiological marker of the intergenerational transmission of risk for depression.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available