Journal
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
Volume 55, Issue 10, Pages 1730-1741Publisher
WILEY
DOI: 10.1002/pola.28539
Keywords
biocompatibility; binding studies; glycopolymers; NMR; polymer modification; polyphosphoramidates; Staudinger reaction; ultracentrifugation; water-soluble polymer
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Funding
- Bulgarian Ministry of Education and Science under project BAS [DFNP-5/20.04.2016]
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A new method for the preparation of poly(oxyethylene phosphoramidate)s and glycopolymers is developed via modification of poly(oxyethylene H-phosphonate) which is a biodegradable, biocompatible and low toxic polymer. The phosphonate groups of the precursor are converted into tri-coordinated phosphorus species yielding poly(oxyethylene trimethylsilyl phosphite). The latter is then reacted with different azides, including sugar azides, via Staudinger reaction to furnish the desired poly(oxyethylene phosphoramidate)s and such containing sugar moieties in the side chains attached to the P-centers. 2002P NMR spectroscopy is applied as a powerful tool for determination of the conversion and structure of the reaction products. Studies on Concanavalin A binding to the obtained glycopolymers are performed using dynamic light scattering and analytical ultracentrifugation techniques. The viability of Human Embryonic Kidney 293 cell line is slightly affected when exposed to polyphosphoramidate glucoconjugate over a broad range of concentrations. The results obtained are encouraging for further investigations on the clustering and bio-recognition properties of the synthesized glycopolymers. (C) 2017 Wiley Periodicals, Inc.
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