Journal
BLOOD SCIENCE
Volume 1, Issue 2, Pages 137-140Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/BS9.0000000000000027
Keywords
Erythropoiesis; Globin regulation; Heme biosynthesis; Long non-coding RNAs
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Funding
- National Key Research and Development Program of China [2016YFA0102300, 2017YFA0103102]
- CAMS Innovation Fund for Medical Sciences [2016-I2M-3-002, 2016-I2M-1-018, 2017-I2M-1-015]
- National Natural Science Foundation of China [81870089, 81700105]
- CAMS Medical Epigenetics Research Center [2018PT31033]
- Fundamental Research Funds for the Central Universities [3332018157]
- State Key Laboratory of Experimental Hematology Research Grant [157-z18-07]
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The transcription of essentially the entire eukaryotic genome produces a huge amount of non-coding RNAs. Among them, long noncoding RNAs (lncRNAs) consist of a significant portion that widely exists across mammal genome, generating from high-throughput transcriptomic studies in the last decade. Although the functions of most lncRNAs remain to be further investigated, many of them have already been shown to play critical roles during normal development and disease conditions. Increasing evidence indicates that lncRNAs involve in versatile biological processes during erythroid proliferation and differentiation, including erythroid cell survival, heme metabolism, globin switching and regulation, erythroid enucleation, etc, via cis- or trans-mediated molecular mechanisms. In this review, we focus on recent advances regarding the functions and mechanisms of lncRNAs in normal erythropoiesis.
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