Maternal nutrient restriction during pregnancy and lactation leads to impaired right ventricular function in young adult baboons

Maternal nutrient restriction induces intrauterine growth restriction (IUGR), increasing later life chronic disease including cardiovascular dysfunction. Our left ventricular (LV) CMRI studies in IUGR baboons (8M, 8F, 5.7years - human equivalent approximately 25years), control offspring (8M, 8F, 5.6years), and normal elderly (OLD) baboons (6M, 6F, mean 15.9years) revealed long-term LV abnormalities in IUGR offspring. Although it is known that right ventricular (RV) function is dependent on LV health, the IUGR right ventricle remains poorly studied. We examined the right ventricle with cardiac magnetic resonance imaging in the same cohorts. We observed decreased ejection fraction (492 vs. 333%, P<0.001), cardiac index (2.730.27 vs. 1.890.20l min(-1) m(-2), P<0.05), early filling rate/body surface area (BSA) (109.27.8 vs. 44.67.3mls(-1)m(-2), P<0.001), wall thickening (61 +/- 3 vs. 44 +/- 5%, P<0.05), and longitudinal shortening (26 +/- 3 vs. 15 +/- 2%, P<0.01) in IUGR animals with increased chamber volumes. Many, but not all, of these changes share similarities to normal older animals. Our findings suggest IUGR-induced pulmonary hypertension should be further investigated and that atrial volume, pulmonic outflow and interventricular septal motion may provide valuable insights into IUGR cardiovascular physiology. Overall, our findings reaffirm that gestational and neonatal challenges can result in long-term programming of poor offspring cardiovascular health. To our knowledge, this is the first study reporting IUGR-induced programmed adult RV dysfunction in an experimental primate model.