Journal
JOURNAL OF PHYSIOLOGY-LONDON
Volume 595, Issue 10, Pages 3041-3051Publisher
WILEY
DOI: 10.1113/JP272781
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Categories
Funding
- NIH [R01AR060037, R01HL061503, K99DK107895]
- Fondation Leducq
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Ryanodine receptors (RyRs) and inositol 1,4,5-trisphosphate receptors (IP3Rs) are calcium (Ca2+) release channelsonthe endo/ sarcoplasmic reticulum(ER/SR). Herewesummarize the latest advances in the field, describing the recently discovered mechanistic roles of intracellular Ca2+ release channels in the regulation ofmitochondrial fitness and endothelial function, providing novel therapeutic options for the treatment of heart failure, hypertension, and diabetes mellitus.
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