4.7 Article

Development of a unique reversible fluorescent probe for tracking endogenous sulfur dioxide and formaldehyde fluctuation in vivo

Journal

CHEMICAL COMMUNICATIONS
Volume 55, Issue 75, Pages 11263-11266

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc04411f

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Funding

  1. NSFC [21472067, 21672083, 21877048]
  2. Taishan Scholar Foundation [TS201511041]
  3. University of Jinan [309-10004]

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A reversible fluorescent probe (NP) for sensing SO2 and FA was rationally constructed. With the outstanding attributes of NP, the fluctuation of endogenous SO2 and FA was successfully traced, not only at the cellular level, but also in living mice for the first time. Significantly, it was first found that the interaction of SO2 and FA can attenuate the cytotoxicity.

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