Journal
CRYSTENGCOMM
Volume 21, Issue 36, Pages 5519-5525Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9ce00872a
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Funding
- National Natural Science Foundation of China [21677081]
- Key Project of Tianjin Natural Science Foundation [18JCZDJC 38100]
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Promoting crystal growth is of great practical importance in the pharmaceutical industry, especially for manufacturing large crystals. In this work, intensification of crystal growth was investigated by using p-toluamide as a model compound. The crystal habit and the functional groups of different crystal faces of p-toluamide were analyzed from the crystal structure data. The growth rate of the (100) and (011) faces of p-toluamide was systematically measured by single crystal experiments and the effect of additives on crystal growth was evaluated. It was found that different additives could selectively promote the growth of specific crystal faces. Molecular simulation was used to investigate the influence mechanism of additives on (011) crystal face growth. It was revealed that the special promotion effect is due to the fact that the additive molecules repel the solvent molecules which exhibit a stronger inhibiting effect, thus eliminating the negative influence of the solvent on the surface diffusion of p-toluamide.
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