Journal
RSC ADVANCES
Volume 9, Issue 49, Pages 28548-28553Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9ra04478g
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Funding
- National Natural Science Foundation of China [31671035, 51803082, 31971316]
- National Significant New Drugs Creation Program [2017ZX09304021]
- Jiangsu Province Foundation [BK20170204, BK20161137]
- Jiangsu Provincial Medical Innovation Team [CXTDA2017024]
- Jiangsu Provincial Commission of Health and Family Planning Foundation [LGY2017088, H2018069, H2017031]
- Jiangsu Provincial Key Medical Discipline [ZDXKA2016017]
- Wuxi Science and Technology Development Foundation [WX18IIAN046]
- Wuxi Commission of Health and Family Planning Foundation [Q201729]
- Innovation Capacity Development Plan of Jiangsu Province [BM2018023]
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In recent years, ferroptosis has been investigated widely as a new form of cell death. Development of nanodrugs for ferroptosis induction in cancer cells may be a promising approach for cancer treatment. Here, we developed a type of nanoparticle consisting of the antitumor drug doxorubicin and exogenous ferritin. The drug loading process did not change the size of ferritin obviously. And this nanoparticle could induce the accumulation of ROS and cell ferroptosis for transferrin receptor overexpressed tumor cell, HT29. The ferroptosis process was also confirmed using inhibitors for ferroptosis. The cytotoxicity of this nanoparticle is similar to that of free DOX. This study provides a new strategy for targeting and killing transferrin receptor overexpressed tumor cells.
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