Journal
RSC ADVANCES
Volume 9, Issue 48, Pages 28119-28125Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9ra04853g
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Funding
- Zhejiang Science and Technology Project [WKJ-zj-1917]
- Zhejiang Health Bureau Fund [2018C37018]
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The quantification capability of high resolution mass spectrometry is of great interest to analysts. We described a method for analysis of multi-class antibiotics in pork meat by UPLC-quadrupole (Q)-Orbitrap-MS. The QuEChERS approach with a clean-up step using a sorbent of primary-secondary amine (PSA) and C18 was adopted for sample preparation, and 37 antibiotics including beta-lactams, tetracyclines, sulfonamides, fluoroquinolones and macrolides were analyzed. The Q-Orbitrap method showed high sensitivity with limits of detection (LODs) ranging from 0.8 mu g kg(-1) to 2.9 mu g kg(-1). The method was further validated by intra and inter-day tests with fortified samples. Recovery (85-105.6%) and precision values (RSDs < 15%) for all analytes were obtained. The result indicates that UPLC-Q-Orbitrap-MS coupled with QuEChERS preparation can serve as a routine method for multi-class antibiotic analysis in pork meat.
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