Journal
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
Volume 8, Issue 17, Pages 4308-4313Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jpclett.7b01758
Keywords
-
Categories
Funding
- Academy of Finland (Centre of Excellence program) [307415]
- European Research Council (Advanced Grant CROWDED-PRO-LIPIDS) [290974]
- Czech Science Foundation [208/12/G016]
- European Research Council (ERC) [290974] Funding Source: European Research Council (ERC)
Ask authors/readers for more resources
The lateral diffusion of embedded proteins along lipid membranes in protein-poor conditions has been successfully described in terms of the Saffman-Delbruck (SD) model, which predicts that the protein diffusion coefficient D is weakly dependent on its radius R as D proportional to ln(1/R). However, instead of being protein-poor, native cell membranes are extremely crowded with proteins. On the basis of extensive molecular simulations, we here demonstrate that protein crowding of the membrane at physiological levels leads to deviations from the SD relation and to the emergence of a stronger Stokes-like dependence D proportional to 1/R. We propose that this 1/R law mainly arises due to geometrical factors: smaller proteins are able to avoid confinement effects much better than their larger counterparts. The results highlight that the lateral dynamics in the crowded setting found in native membranes is radically different from protein-poor conditions and plays a significant role in formation of functional multiprotein complexes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available