Journal
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
Volume 8, Issue 7, Pages 1604-1609Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jpclett.7b00270
Keywords
-
Categories
Funding
- CSIR-NCL
- SERB, India [SR/S2/RJN-142/2012, SR/S2/RJN-84/2012]
- CSIR XIIth five year plan project on Multiscale modelling [CSC0129]
- National Research Foundation of Korea [2011-0015061]
- UNIST, Korea
- National Research Foundation of Korea [2011-0015061] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Ask authors/readers for more resources
Cosolvents have versatile composition-dependent applications in chemistry and biology. The simultaneous presence of hydrophobic and hydrophilic groups in dimethyl sulfoxide (DMSO), an industrially important amphiphilic cosolvent, when combined with the unique properties of water, plays key roles in the diverse fields of pharmacology, cryoprotection, and cell biology. Moreover, molecules dissolved in aqueous DMSO exhibit an anomalous concentration-dependent nonmonotonic behavior in stability and activity near a critical DMSO mole fraction of 0.15. An experimental identification of the origin of this anomaly can lead to newer chemical and biological applications. We report a direct spectroscopic observation of the anomalous behavior using ultrafast twodimensional infrared spectroscopy experiments. Our results demonstrate the cosolventconcentration-dependent nonmonotonicity arises from nonidentical mechanisms in ultrafast hydrogen-bond-exchange dynamics of water above and below the critical cosolvent concentration. Comparison of experimental and theoretical results provides a molecular-level mechanistic understanding: a distinct difference in the stabilization of the solute through dynamic solute solvent interactions is the key to the anomalous behavior.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available