Journal
JOURNAL OF PHYSICAL CHEMISTRY C
Volume 121, Issue 12, Pages 6626-6634Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jpcc.6b12097
Keywords
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Funding
- NSF [CHE-1363008, CHE-1416268]
- NIH [1R21EB018014, U01 CA202229, 1R21EB020323]
- DOD CDMRP [W81XWH-15-1-0271, W81XWH-12-1-0159/BC112431]
- Exxon Mobil Knowledge Build
- Duke University
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1363008] Funding Source: National Science Foundation
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1416268] Funding Source: National Science Foundation
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Signal Amplification by Reversible Exchange (SABRE) is a fast and convenient NMR hyperpolarization method that uses cheap and readily available para-hydrogen as a hyperpolarization source. SABRE can hyperpolarize protons and heteronuclei. Here we focus on the heteronuclear variant introduced as SABRE-SHEATH (SABRE in SHield Enables Alignment Transfer to Heteronuclei) and nitrogen-15 targets in particular. We show that N-15-SABRE works more efficiently and on a wider range of substrates than H-1-SABRE, greatly generalizing the SABRE approach. In addition, we show that nitrogen-1s offers significantly extended T-1 times of up to 12 minutes. Long T-1 times enable higher hyperpolarization levels but also hold the promise of hyperpolarized molecular imaging for several tens of minutes. Detailed characterization and optimization are presented, leading to nitrogen-15 polarization'evels in excess of 10% on several compounds.
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