Journal
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 81, Issue 3, Pages 565-568Publisher
INDIAN PHARMACEUTICAL ASSOC
DOI: 10.36468/pharmaceutical-sciences.546
Keywords
Diospyros lotus; Ebenaceae; diospyrin; PTP1B; molecular docking
Categories
Funding
- Higher Education Commission
Ask authors/readers for more resources
The present study was designed to evaluate the antidiabetic potential of diospyrin isolated from Diospyros lotus, using protein tyrosine phosphatase 1B enzyme as the target. Molecular binding mode of diospyrin to protein tyrosine phosphatase 1B was essential to explore its molecular interactions. Molecular docking, the simulation technique used to model the interaction between two molecules were performed using Open Eye software. This compound exhibited significant protein tyrosine phosphatase 1B inhibitory activity (IC50 value: 27.59 +/- 0.03 mu M). Molecular docking studies showed significant molecular interactions of the diospyrin with Gly 220, Tyr 46, Val 49 and Asp 48 inside the active site of protein tyrosine phosphatase 1B. The in silico result builds prospect that diospyrin can be further developed as a new lead compound targeting protein tyrosine phosphatase 1B inhibition.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available