Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 144, Issue -, Pages 148-161Publisher
ELSEVIER
DOI: 10.1016/j.addr.2019.08.010
Keywords
Foreign body response; Implantation; Diabetes; Cell encapsulation; Devices; Immunology; Alginate; Zwitterionic; Hydrogel; Fibrosis; Biomaterials; Immunomodulation
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Funding
- National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases (United States) [NIH NIDDK RFA-DK-15-030, NIH NIDDK 5R01DK120459]
- CPRIT (United States) [RR160047]
- JDRF (United States) [PNF-2018-662-S-B]
- Sigilon Therapeutics SRA (United States)
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The foreign body response is an immunological process that leads to the rejection of implanted devices and presents a fundamental challenge to their performance, durability, and therapeutic utility. Recent advances in materials development and device design are now providing strategies to overcome this immune-mediated reaction. Here, we briefly review our current mechanistic understanding of the foreign body response and highlight new anti-FBR technologies from this decade that have been applied successfully in biomedical applications relevant to implants, devices, and cell-based therapies. Further development of these important technologies promises to enable new therapies, diagnostics, and revolutionize the management of patient care for many intractable diseases. (C) 2019 Published by Elsevier B.V.
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