Journal
CLINICAL & TRANSLATIONAL IMMUNOLOGY
Volume 8, Issue 9, Pages -Publisher
WILEY
DOI: 10.1002/cti2.1078
Keywords
gamma delta T cells; transplant immunology; graft-versus-host disease
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Gamma delta (gamma delta) T cells are a highly heterogeneous population of lymphocytes that exhibit innate and adaptive immune properties. Despite comprising the majority of residing lymphocytes in many organs, the role of gamma delta T cells in transplantation outcomes is under-researched. gamma delta T cells can recognise a diverse array of ligands and exert disparate effector functions. As such, they may potentially contribute to both allograft acceptance and rejection, as well as impacting on infection and post-transplant malignancy. Here, we review the current literature on the role and function of gamma delta T cells following solid organ and hematopoietic stem cell transplantation.
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