Journal
CHEMICAL COMMUNICATIONS
Volume 55, Issue 77, Pages 11551-11554Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc05592d
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Funding
- National Key Research and Development Program of China [2016YFA0201301]
- National Natural Science Foundation of China [21435005, 21627808, 21721003]
- Key Research Program of Frontier Sciences, CAS [QYZDY-SSW-SLH019]
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A novel ratiometric electrochemiluminescence (ECL)-electrochemical (EC) hybrid biosensor with a high accuracy and reproducibility was fabricated for the ultrasensitive detection of miRNA-133a. With the help of a DNA tetrahedron nanostructure and hybridization chain reaction dual amplification strategy, the detection limit of 12.17 aM for miRNA-133a was obtained.
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