Journal
CHEMICAL COMMUNICATIONS
Volume 55, Issue 77, Pages 11567-11570Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc04416g
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Funding
- National Natural Science Foundation of China [21801057, 21871072, 21775166]
- Natural Science Foundation for Distinguished Young Scholars of Jiangsu Province [BK20180026]
- Hangzhou Normal University [2018PYXML009, 2018QDL002, 2018YLXK16]
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A small series of fluorescent lysosome-targeting probes based on the BODIPY fluorophore and containing morpholine and nitro groups were rationally designed. These probes emitted light from green to NIR wavelengths, and provided specificity for imaging the lysosomes of hypoxic cells. The electron-withdrawing nitrophenyl group at the meso position was found to lead to highly efficient nonradiative decay of the S-1 state, and hence a recovery of fluorescence when reduction of the nitro group occurred under hypoxic conditions.
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