Journal
COMMUNICATIONS BIOLOGY
Volume 2, Issue -, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s42003-019-0611-3
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Funding
- European Academy of Neurology
- PREMIO JOAO LOBO ANTUNES SCML
- Agence Nationale de la Recherche [ANR-13-JSV4-0001-01]
- European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme [818521]
- Fondation pour la Recherche Medicale [FRM DEQ20150331725]
- Agence Nationale de la Recherche (ANR) [ANR-13-JSV4-0001] Funding Source: Agence Nationale de la Recherche (ANR)
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The brain is constituted of multiple networks of functionally correlated brain areas, out of which the default-mode network (DMN) is the largest. Most existing research into the DMN has taken a corticocentric approach. Despite its resemblance with the unitary model of the limbic system, the contribution of subcortical structures to the DMN may be underappreciated. Here, we propose a more comprehensive neuroanatomical model of the DMN including subcortical structures such as the basal forebrain, cholinergic nuclei, anterior and mediodorsal thalamic nuclei. Additionally, tractography of diffusion-weighted imaging was employed to explore the structural connectivity, which revealed that the thalamus and basal forebrain are of central importance for the functioning of the DMN. The contribution of these neurochemically diverse brain nuclei reconciles previous neuroimaging with neuropathological findings in diseased brains and offers the potential for identifying a conserved homologue of the DMN in other mammalian species.
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