Photocatalysis effect of a novel green synthesis gadolinium doped titanium dioxide nanoparticles on their biological activities

We report the synthesis of gadolinium doped titanium dioxide (GdT) nanoparticles (NPs) via hydrothermal method using a novel bioreductant Piper betel leaf. The physiochemical properties of green synthesized GdT NPs were characterized using various techniques. The results reveal that GdT NPs have attached with the biomolecules which were supporting evidence for the reduction and capping agents. GdT NPs have crystalline in nature and their estimated grain size is of about 5.45 nm by the Scherer's formula. GdT NPs consist of well-dispersed agglomerates of grains with a narrow size distribution of about 4 nm to 7 nm and are having spherical in nature. GdT NPs are thermally stable. In addition, GdT NPs were subjected to antimicrobial and antioxidant assays. Herein, we observed that the GdT NPs show higher antibacterial activities against Staphylococcus aureus as compared with Escherichia coli and the minimum inhibitory concentration (MIC) value was found to be 25 mu g mL(-1) under UV irradiation condition for both the cases. Furthermore, antioxidant activities of GdT NPs were evaluated in vitro, using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical cation decolorization test. Results suggest that GdT NPs give promising antioxidant activity as compared to standard ascorbic acid and Piper betel leaf. This novel and efficient strategy will show the route for avoiding the use of toxic solvents and a promising green route to restrict for drug discovery from natural products. Thus, the present findings may shine in the field of green pharmaceuticals industries. (C) 2017 Elsevier B.V. All rights reserved.