Journal
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
Volume 333, Issue -, Pages 213-219Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jphotochem.2016.10.030
Keywords
Fluorescent probe; Coumarin-naphthol conjugate; Schiff base; Imine hydrolysis; Copper ion
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Funding
- Key Project of National Natural Science Foundation of China [81430092]
- Ph.D. Programs Foundation of Ministry of Education of China [20120096130002]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT_15R63]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
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An off-on fluorescent probe (CuCIN), coumarin-naphthol linked by an imine group, for detecting Cu2+ in DMSO-HEPES buffer (1:99, v/v) solution was successfully developed. Mechanism studies suggested that CuCIN firstly formed a complex with Cu2+ in a 1:2 metal-to-ligand ratio, and then 60-fold fluorescence enhancement was observed when Cu2+ promoted the imine hydrolysis to release the fluorescence compound 7-diethylaminocoumarin-3-aldehyde. This probe displayed desired properties such as high selectivity toward other metal ions, low detection limit (12.7 nM) and low cytotoxicity. Bio-imaging study revealed that the new probe CuCIN could be applied for imaging living cells with good cell permeability. We hope to apply this probe in the biomedical research field for the imaging of disease-relevant Cu2+. (C) 2016 Elsevier B.V. All rights reserved.
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