Journal
BIOMEDICINES
Volume 7, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/biomedicines7030055
Keywords
thrombotic event; aptamer; DNA; RNA; SELEX; molecular recognition element (MRE); monitoring; treatment
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Funding
- Wilkes University Research and Scholarship Fund
- Department of Pharmaceutical Sciences at Wilkes University
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The unique opportunity for aptamer uses in thrombotic events has sparked a considerable amount of research in the area. The short half-lives of unmodified aptamers in vivo remain one of the major challenges in therapeutic aptamers. Much of the incremental successful therapeutic aptamer stories were due to modifications in the aptamer bases. This mini-review briefly summarizes the successes and challenges in the clinical development of aptamers for thrombotic events, and highlights some of the most recent developments in using aptamers for anticoagulation monitoring.
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