Journal
JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 106, Issue 6, Pages 1453-1465Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.xphs.2017.02.006
Keywords
capsules; gelatin; hypromellose; cross-linking; modified release; enteric; stability
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Capsules offer an alternate to tablets for oral delivery of therapeutic compounds. One advantage of capsules over tablets is their amenability to deliver not only solids but also nonaqueous liquids and semisolids as a unit dose solid dosage form. Shell component is an essential part of capsule dosage forms. Capsule shells, available as hard or soft shells, are formulated from gelatin or a non-gelatin polymeric material such as hypromellose and starch, water, and with or without a nonvolatile plasticizer. The capsule shells may also be formulated to modify the release of their fill contents in a site-specific manner in the gastrointestinal tract. The goal of the current review is to provide an in-depth discussion on polymeric film-forming materials and manufacturing technologies used in the production of capsule shells. (C) 2017 American Pharmacists Association (R). Published by Elsevier Inc. All rights reserved.
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