Journal
FRONTIERS IN BIOSCIENCE-LANDMARK
Volume 24, Issue -, Pages 765-776Publisher
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/4749
Keywords
TGCTs; microRNAs; OncomiRs; Tumor suppressor; Review
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Funding
- Young Elite Scientists Sponsorship Program by CAST [YESS20160118]
- National Natural Science Foundation of China [31471352, 31501198]
- CAS-TWAS President's Fellowship for International PhD Students
- Clinical Capability Construction Project for Liaoning Provincial Hospitals [LNCCC-C09-2015, LNCCC-D50-2015]
- Academician Workstation Support (Shenyang)
- Academician Workstation Support (Changsha)
- Academician Workstation Support (Shandong)
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Testicular germ cell tumors (TGCTs) are generally rare but represent the most common solid tumors in young men. They are classified broadly into seminoma, which resemble primordial germ cells (PGCs), and non-seminoma, which are either undifferentiated (embryonic carcinoma) or differentiated (teratoma, yolk sac tumor, choriocarcinomas) patterning. A widespread role for microRNAs (miRNAs), in diverse molecular processes driving initiation and progression of various types of TGCTs has been recently studied. We discuss the involvement of different miRNAs in the development and progression of different types of TGCTs. Moreover, we highlight the aberrant expression of miRNAs in TGCTs and several targets, which may define miRNAs as oncomiRs or tumor suppressors. A better understanding of miRNA biology may ultimately yield further insight into the molecular mechanisms of tumorigenesis and new therapeutic strategies against TGCTs.
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