Journal
ACS APPLIED BIO MATERIALS
Volume 2, Issue 10, Pages 4667-4674Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.9b00747
Keywords
synthetic melanin nanoparticles; synthesis; polydopamine; UV irradiation; facile preparation; melanin; mechanism
Funding
- National Institutes of Health (NIH) Institutional National Research Service Award [T32 CA153915]
- NIH [R00 HL117048, DP2 HL137187, S10 OD021821, S10 OD023555]
- National Institutes of Health Award [S10 OD023527]
- National Science Foundation [ECCS-1542148]
- UC Cancer Research Coordinating Committee
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Synthetic melanin nanoparticles have value in metal chelation, photoprotection, and biocompatibility. Applications of these materials have been reported in optics, biomedicine, and electronics. However, precise size control has remained relatively difficult-especially for materials below 1000 nm. In this paper we describe the synthesis of ultrasmall synthetic nanoparticles with size of 9.4-31.4 nm in weakly acidic and neutral conditions via UV-irradiation. Size control of these particles was possible by varying the pH from 6.4-10.0. We then used UV-vis, FTIR, and nuclear magnetic resonance to investigate the mechanism of UV-induced polymerization. The data show that reactive oxygen species from UV irradiation oxidizes intermediates of the reaction and accelerates the formation of these synthetic melanin structures.
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