Journal
ENVIRONMENTAL SCIENCE-NANO
Volume 6, Issue 10, Pages 3072-3079Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9en00807a
Keywords
-
Funding
- National Science Foundation of China [51478453, 21776163]
- Shandong Provincial Natural Science Foundation [ZR2019JQ18]
- Open Project of the Key Laboratory of Environmental Biotechnology, CAS [kf2018010]
- Qilu Youth Talent Programme of Shandong University
- Fundamental Research Funds of Shandong University [2017JC021]
Ask authors/readers for more resources
Recently, there has been increasing global concerns about the ecological impact of micro- and nano-sized polystyrene particles in marine environments. However, the potential threats of polystyrene nanoparticles to primary producers in freshwater systems remain unclear. Here, we explore the metabolite profiles and signaling pathways of freshwater cyanobacterium Synechococcus elongatus in response to short-term (48 h) amino-modified polystyrene nanoparticle (PS-NH2; 50 nm) exposure. We demonstrate that the positively charged PS-NH2 were acutely toxic to S. elongatus with an EC50 of 3.81 mu g mL(-1). Non-targeted metabolomics analyses suggested oxidative stress and membrane destruction as the main causes of PS-NH2 toxicity. Furthermore, disruption of glutathione metabolism and damage to membrane integrity were confirmed using two engineered strains of S. elongatus. These results provide new insights into polystyrene nanoparticles' impact on primary producers, improving the understanding of the toxic mechanisms of polystyrene nanoparticles in the freshwater primary producers.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available