Journal
CHINESE JOURNAL OF ORGANIC CHEMISTRY
Volume 39, Issue 9, Pages 2412-2427Publisher
SCIENCE PRESS
DOI: 10.6023/cjoc201902012
Keywords
maleimide; Michael addition; oxidative coupling; cycloaddition reaction
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Funding
- Shanghai Municipal Natural Science Foundation [15ZR1401400]
- National Undergraduate Training Program for Innovation and Entrepreneurship in Donghua University
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Maleimide, a common motif in a variety of natural alkaloids, has been extensively investigated due to its noteworthy biological activities and optical properties. Additionally, it can be transformed into many important heterocyclic frameworks such as succinimides, pyrrolidines, and 2-pyrrolidones. Thus, a great deal of attention has been focused on the development of new synthetic routes to access polyfunctionalized maleimides. In this article, the recent research progress in functionalization of double bond is reviewed based on maleimides according to Michael addition, oxidative coupling and cycloaddition reaction.
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