Journal
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
Volume 30, Issue 5, Pages 525-530Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/jpem-2016-0344
Keywords
brain-derived neurotrophic factor; child and adolescents; glucose tolerance test; insulin; platelets
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Funding
- Ministry of Education, Culture, Sports, Science and Technology, Japan [25860893, 21591340]
- Grants-in-Aid for Scientific Research [25860893, 21591340] Funding Source: KAKEN
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Background: Little is known regarding the relationships among circulating brain-derived neurotrophic factor (BDNF) levels and glucose or insulin in children and adolescents. The objective of this study was to investigate whether circulating BDNF levels would change during the oral glucose tolerance test (OGTT). Methods: We performed the OGTT and measured the serial changes in BDNF levels in both plasma and serum. Results: There were 22 subjects in the normal type (N) group and 20 in the borderline/diabetic type (B/D) group, defined by the results of the OGTT. Serum levels of BDNF were almost five times higher and plasma levels gradually decreased during the OGTT, whereas serum levels showed no significant change. The reduction of plasma BDNF level changes from baseline to 120 min were significantly different between the N and B/D groups (36.3% vs. 20.8%, p = 0.023). Conclusions: Our results showed that plasma levels of BDNF are more sensitive to acute changes in glucose or insulin levels than serum.
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