Journal
JOURNAL OF PATHOLOGY
Volume 243, Issue 2, Pages 155-159Publisher
WILEY
DOI: 10.1002/path.4943
Keywords
pancreatic adenosquamous carcinoma (PASC); mixed cancer; TP53; 3p loss
Funding
- Science & Technology Commission of Shanghai [15JC1402800, 14XD1402800]
- Shanghai Eastern Youth Scholar Programme
- National High Technology Research and Development Programme of China (863 Programme) [2015AA020403]
- National Key Research and Development Programme [2016YFC0900100]
- Beijing Municipal Science and Technology Commission [Z141100000214013]
- Recruitment Programme of Global Youth Experts
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In pancreatic cancer, pancreatic adenosquamous carcinoma (PASC) containing both ductal adenocarcinoma and squamous carcinoma in the same tumour represents similar to 4% of the total incidence. To date, the genomic features of this mixed tumour are still unknown. We analysed the genomes of 17 PASCs and 34 pancreatic ductal adenocarcinomas (PDACs), and showed that PASC carried highly enriched TP53 mutations and 3p loss as compared with PDAC. We also showed that adenomatous and squamous components of PASC harboured comparable genomic alterations, suggesting that the two cellular components develop from the same progenitor cancer cells. Our study has updated genomic knowledge to help with understanding mixed cancers of the pancreas. Copyright (C) 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
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