Journal
INTERNATIONAL IMMUNOLOGY
Volume 31, Issue 9, Pages 569-577Publisher
OXFORD UNIV PRESS
DOI: 10.1093/intimm/dxy086
Keywords
lipid metabolites; dietary oil; intestinal bacteria; inflammatory disease; allergy
Categories
Funding
- Ministry of Education, Culture, Sports, Science, and Technology of Japan (MEXT)
- Japan Society for the Promotion of Science (JSPS) [KAKENHI JP15K19142, JP15H05790, JP18H02150, JP18H02674, JP17K09604, JP26670241, JP26293111]
- Japan Agency for Medical Research and Development (AMED) [JP17ek0410032s0102, JP17ek0210078h0002, JP17ak0101068h0001, JP17gm1010006s0101, JP18ck0106243h0003]
- Ministry of Health and Welfare of Japan
- Science and Technology Research Promotion Program for Agriculture, Forestry, Fisheries, and Food Industry
- MEXT [JP23116506, JP16H01373, JP25116706]
- Ono Medical Research Foundation
- Canon Foundation
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The gastrointestinal tract is continuously exposed to the external environment, which contains numerous non-self antigens, including food materials and commensal micro-organisms. For the maintenance of mucosal homeostasis, the intestinal epithelial layer and mucosal immune system simultaneously provide the first line of defense against pathogens and are tightly regulated to prevent their induction of inflammatory responses to non-pathogenic antigens. Defects in mucosal homeostasis lead to the development of inflammatory and associated intestinal diseases, such as Crohn's disease, ulcerative colitis, food allergy and colorectal cancer. The recent discovery of novel dietary omega 3 and omega 6 lipid-derived metabolites-such as resolvin, protectin, maresin, 17,18-epoxyeicosatetraenoic acid and microbe-dependent 10-hydroxy-cis-12-octadecenoic acid-and their potent biologic effects on the regulation of inflammation have initiated a new era of nutritional immunology. In this review, we update our understanding of the role of lipid metabolites in intestinal inflammation.
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