Journal
JOURNAL OF ORTHOPAEDIC TRAUMA
Volume 31, Issue -, Pages S25-S31Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/BOT.0000000000000803
Keywords
supplemental perioperative oxygen; surgical site infection; tibial plateau fractures; tibial pilon fractures; calcaneus fractures
Categories
Funding
- [DOD CDMRP W81XWH-12-1-0588]
Ask authors/readers for more resources
Supplemental perioperative oxygen (SPO) therapy has been proposed as one approach for reducing the risk of surgical site infection (SSI). Current data are mixed regarding efficacy in decreasing SSI rates and hospital inpatient stays in general and few data exist for orthopaedic trauma patients. This study is a phase III, double-blind, prospective randomized clinical trial with a primary goal of assessing the efficacy of 2 different concentrations of perioperative oxygen in the prevention of SSIs in adults with tibial plateau, pilon (tibial plafond), or calcaneus fractures at higher risk of infection and definitively treated with plate and screw fixation. Patients are block randomized (within center) in a 1:1 ratio to either treatment group (FiO(2) 80%) or control group (FiO(2) 30%) and stratified by each study injury location. Secondary objectives of the study are to compare species and antibacterial sensitivities of the bacteria in patients who develop SSIs, to validate a previously developed risk prediction model for the development of SSI after fracture surgery, and to measure and compare resource utilization and cost associated with SSI in the 2 study groups. SPO is a low cost and readily available resource that could be easily disseminated to trauma centers across the country and the world if proved to be effective.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available