Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 82, Issue 24, Pages 13003-13011Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.7b01489
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Funding
- National Natural Science Foundation of China [21602032, 61671162]
- Technology Plan of Guangdong Province [2016A010103031]
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Selective C-H bond alkynylation toward modular access to material and pharmaceutical molecules is of great desire in modern organic synthesis. Reported herein is Ir(III)-catalyzed regioselective C-H alkynylation of ketones and esters, which is generally applicable for the rapid construction of molecular complexity. This protocol provides a complementary process for conventional alkyne synthesis. Further functionalization of carbonyl-derived material molecules and pharmaceuticals demonstrates the potential synthetic utility of this methodology.
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