Journal
NATURAL PRODUCT REPORTS
Volume 36, Issue 10, Pages 1437-1461Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8np00080h
Keywords
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Funding
- BLUEandGREEN project (H2020 TWINNING) [692419]
- European Research Council (ERC) [759840]
- National Science Foundation (NSF) [CHE-1454007]
- Fundacao para a Ciencia e a Tecnologia (FCT) (COMPETE 2020, Portugal 2020, ERDF) [PTDC/BIA-BQM/29710/2017, UID/Multi/04423/2013]
- Fundacao para a Ciencia e a Tecnologia (FCT) [SFRH/BD116009/2016, IF/01358/2014]
- Fundação para a Ciência e a Tecnologia [PTDC/BIA-BQM/29710/2017] Funding Source: FCT
- European Research Council (ERC) [759840] Funding Source: European Research Council (ERC)
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Covering: up to 2019 Alkylresorcinols are amphiphilic metabolites, well-known for their diverse biological activities, produced by both prokaryotes and eukaryotes. A few classes of alkylresorcinol scaffolds have been reported from the photoautotrophic cyanobacteria, ranging from the relatively simple hierridins to the more intricate cylindrocyclophanes. Recently, it has emerged that cyanobacteria employ two different biosynthetic pathways to produce unique alkylresorcinol scaffolds. However, these convergent pathways intersect by sharing biosynthetic elements which lead to common structural motifs. To obtain a broader view of the biochemical diversity of these compounds in cyanobacteria, we comprehensively cover the isolation, structure, biological activity and biosynthesis of their mono- and dialkylresorcinols. Moreover, we provide an overview of the diversity and distribution of alkylresorcinol-generating biosynthetic gene clusters in this phylum and highlight opportunities for discovery of novel alkylresorcinol scaffolds. Because some of these molecules have inspired notable syntheses, different approaches used to build these molecules in the laboratory are showcased.
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