4.7 Article

Diastereoselective Synthesis of Substituted Morpholines from N-Tethered Alkenols: Total Synthesis of (±)-Chelonin A

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 82, Issue 3, Pages 1330-1339

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.6b02260

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Funding

  1. Council of Scientific and Industrial Research (CSIR), New Delhi [02/0159/13/EMR-II]

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Intramolecular cyclization of nitrogen tethered alkenols catalyzed by palladium chloride leads to substituted morpholines in good yields. The methodology was used for the total synthesis of (+/-)-chelonin A.

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