Mn(OAc)3-Promoted Oxidative Csp3-P Bond Formation through Csp2-Csp2 and P-H Bond Cleavage: Access to β-Ketophosphonates

The Mn(OAc)(3)-promoted oxidative phosphonylation of N,N-dimethylenaminones with H-phosphonates, involving a chemo- and regioselective C-sp(2)-C-sp(2) bond cleavage and C-sp(3)-P bond formation in one step, provided successfully functionalized beta-ketophosphonates under mild reaction conditions. Oxidative C-sp(3)-H/P H cross-coupling reactions via C-sp(3)-C(C=O) bond cleavage and mechanistic studies are conducted preliminarily, and a possible mechanism is proposed. This novel method proceeds in good to excellent yields, shows operational simplicity, broad substrate scope, and large-scale preparation.