4.7 Article

Sustainable Difluoroalkylation Cyclization Cascades of 1,8-Enynes

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 82, Issue 8, Pages 4449-4457

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.7b00350

Keywords

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Funding

  1. National Natural Science Foundation of China [21402028]
  2. Fuzhou University [XRC-1331]

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We reported a visible-light-induced difluoroalkylation and cyclization cascade reaction of 1,8-enynes with broad substrate scopes in Up to 92% isolated yields. This: method provides a sustainable and efficient access to the synthesis of difluoroalkylated tetracyclic compounds under. mild conditions.

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