Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 82, Issue 8, Pages 4007-4019Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.6b02887
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- RWTH Aachen University - Excellence Initiative of the German federal and state governments
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Mechanochemical activation achieved by grinding, shearing, pulling, or milling opens unique opportunities in synthetic organic chemistry. Common features are that mechanochemistry facilitates reactions with insoluble reactants, enables high-yielding solvent-free synthetic procedures, and shortens reaction times, among others. However, mechanochemical techniques can also alter chemical reactivity and selectivity compared-to the analogous solution-based protocols. As a consequence, solvent-free milling, can lead to different product compositions or equilibration mixtures than in solution. Reactions by milling have also allowed the trapping and characterization of elusive intermediates and materials. In this Perspective we highlight a few selected examples that illustrate the value of mechanochemistry in uncovering interesting chemical reactivity, which is often masked in typical liquid-phase synthesis.
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