Synthesis of 1-Amino-1H-Indenes via a Sequential Suzuki-Miyaura Coupling/Petasis Condensation Sequence

An efficient and straightforward synthesis of 1-amino-1H-indenes is reported from 1,2-bis(boronates) via a sequential Suzuki Miyaura coupling/Petasis cydization reaction. Starting from the same monoboronic ester intermediates, an intermolecular version of this approach also afforded (Z)-alpha,beta-unsaturated amino esters in moderate to good yields.