4.7 Article

Dimethyl Sulfoxide Involved One-Pot Synthesis of Quinoxaline Derivatives

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 82, Issue 7, Pages 3491-3499

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.6b02977

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Funding

  1. National Science Foundation of China [21572117]
  2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences [GTZK201405]
  3. Peking Union Medical College [GTZK201405]

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An efficient, green, and novel method for the synthesis of N-heterocycle-fused quinoxalines is repotted herein. Dimethyl sulfoxide was used as both a reactant and a solvent in this reaction. A wide range of products in moderate to excellent yields were obtained, including pyrrolo[1,2-a]quinoxalines, indolo[1,2-a]quinoxalines, 1H-pyrrolo[3,2-c]quinoliries, and benzo [4,5]imidazo [1,2-c] quinazolines.

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