The effect of polyvinylpyrrolidone nanowires on the metabolic activity of Lactobacillus acidophilus

The effectiveness of the use of polyvinylpyrrolidone (PVP) nanowires for increasing the metabolic activity of probiotic cultures of Lactobacillus acidophilus has been shown. PVP nanowires are obtained by electrospinning in two versions: PVPI based on a solution of high molecular weight polyvinylpyrrolidone and distilled water; PVPII based on a solution of two water zinc acetate in distilled water and a solution of high molecular weight PVP in ethanol. In the presence of PVP, there was an increase in viable lactobacillus cells up to 7.4 x 10(8) CFU/ml and accumulation of DL-lactic acid during acidification of the test solution to 3.10 and an increase in Eh to + 360.5 mV. PVPI is a more preferred carrier for lactobacilli than PVPII with ZnO. The zinc ions contained in the PVP matrix are capable of causing oxidative stress, followed by the formation of free radicals that damage membrane lipids, proteins and DNA of the prokaryotic cell. The results are aimed at developing new forms of immobilized drugs that can be used as alternative probiotic agents.